Adenoviral vectors for treating disease

Details Adenoviral vectors for treating disease Adenoviral vectors for treating disease

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) C12N 15/28 (2006.01) C12N 15/55 (2006.01)

Patent

CA 2373352

Adenoviral vectors, including mutant adenoviruses, that have restriction sites in the E3 region, that facilitate its partial or total deletion, or select genes contained therein, and compositions and methods for substituting heterologous gene(s), if desired, which gene(s) will exhibit an expression pattern, both in terms of timing and degree of expression, similar to the endogenous adenoviral gene that it replaces, and further optionally including mutations in other parts of the adenoviral genome, including certain E1B or E1A regions, and that have applications for diagnosing or treating disease, preferably disease involving unwanted cell growth, including cancer.

L'invention concerne des vecteurs adénoviraux, notamment des adénovirus mutants, présentant des sites de restriction dans la région E3, facilitant sa délétion partielle ou totale, ou sélectionnant des gènes contenus dans celle-ci, ainsi que des compositions et des méthodes de substitution de gène(s) hétérologue(s), si désiré, lequel/lesquels gènes présentent un type d'expression, à la fois en termes de durée et de degré d'expression, semblable à celui du gène adénoviral endogène qu'il remplace, et comportant également facultativement des mutations dans d'autres parties du génome adénoviral, notamment certaines régions E1B ou E1A, et ayant des applications en diagnostic ou en traitement de maladies, de préférence des maladies à croissance cellulaire indésirable, notamment le cancer.

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