Adenoviral vectors including dna encoding lung surfactant...

Details Adenoviral vectors including dna encoding lung surfactant... Adenoviral vectors including dna encoding lung surfactant...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C07K 14/785 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2160136

An adenoviral vector including a DNA sequence encoding a lung surfactant protein. The adenoviral vector may be a replication deficient adenoviral vector which is free of at least the majority of the E1 and E3 DNA sequences. Such vectors may be employed for generation of infectious viral particles which may transduce lung epithelial cells in vivo to enable the expression of lung surfactant protein by such cells.

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