Adenoviral vectors with modified tropism

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 47/48 (2006.01) C07K 16/08 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) C12N 15/861 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2283461

The present invention relates to gene therapy. In particular, therapeutic agents, therapeutic gene products, and compositions are disclosed. Various systems and methods useful in targeting and delivering non-native nucleotide sequences to specific cells are disclosed, wherein virus-antibody-ligand conjugates are used to facilitate targeting and delivery.

La présente invention concerne de façon générale les thérapies géniques, et plus particulièrement des agents thérapeutiques, des produits géniques à vocation thérapeutique et des compositions. L'invention concerne également différents systèmes et procédés convenant au ciblage et à l'introduction de séquences de nucléotides non natives dans des cellules spécifiques, auquel cas des conjugués virus-anticorps-ligand favorisent ce ciblage et cette introduction.

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