Adenovirus 36 e4 orf 1 gene and protein and their uses

Details Adenovirus 36 e4 orf 1 gene and protein and their uses Adenovirus 36 e4 orf 1 gene and protein and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/34 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 3/10 (2006.01) A61P 5/50 (2006.01) C07K 14/075 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2632013

Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis. Ad-36 E4 orf 1 protein can be used to increase insulin sensitivity and ameliorate diabetes. Additionally, drugs that mimic the action of Ad-36 E4 orf 1 protein could be found. Ad-36 E4 orf 1 could also be used to increase fat cells in lipodystrophy. We have also discovered that Ad-36 infection in human skeletal muscle cells increased differentiation and insulin independent glucose uptake. It is expected that infection with Ad-36 E4 orf 1 gene will also cause these effects.

Selon l'invention, il a été découvert que l'expression du gène E4 orf 1 de l'Ad-36 seule est responsable de la sensibilité accrue à l'insuline observée chez des animaux infectés par Ad-36, y compris une adipogenèse accrue. La protéine E4 orf 1 de l'Ad-36 peut être utilisée pour augmenter la sensibilité à l'insuline et améliorer l'état des diabétiques. De plus, on peut trouver des médicaments qui imitent l'action de la protéine E4 orf 1 de l'Ad-36. E4 orf 1 de l'Ad-36 peut également être utilisé pour augmenter les cellules adipeuses dans la lipodystrophie. Nous avons également découvert qu'une infection par Ad-36 des cellules des muscles du squelette humain augmente la différentiation et l'absorption de glucose indépendante de l'insuline. On s'attend à ce qu'une infection par le gène E4 orf 1 de l'Ad-36 cause elle aussi de tels effets.

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