Adenovirus-derived viral vectors having two therapeutic...

Details Adenovirus-derived viral vectors having two therapeutic... Adenovirus-derived viral vectors having two therapeutic...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/52 (2006.01) A61K 31/70 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C07K 14/035 (2006.01) C07K 14/535 (2006.01) C07K 14/55 (2006.01) C07K 14/82 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/19 (2006.01) C12N 15/54 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2200629

Novel adenovirus-derived viral vectors, preparation thereof, and use thereof in gene therapy. In particular, defective recombinant adenoviruses including two therapeutic genes, i.e. a suicidal gene and an immunopotentiating or tumour-suppressor gene, are disclosed.

La présente invention concerne de nouveaux vecteurs viraux dérivés des adénovirus, leur préparation et leur utilisation en thérapie génique. Elle concerne plus particulièrement des adénovirus recombinants défectifs comprenant deux gènes thérapeutiques, le premier étant un gène suicide et le second un gène immunostimulant ou un gène suppresseur de tumeurs.

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