C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/34 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2177085
The present invention relates to adenovirus (Ad) El- complementing cell lines which significantly reduce the presence of replication competent Ad (RCA) and can serve for the large scale production of infectious El- deleted adenoviral particles that may be used for the treatment human patients as for example in gene therapy. As well the invention relates to a method for the large scale production of recombinant infectious adenoviral particles harboring an exogenous sequence of interest and to a RCA-free stock of infectious adenoviral particles. The invention further relates to a recombinant vector for transfecting an eukaryotic cell line in order to construct Ad E1-complementing cell lines which significantly reduce the presence of RCA and to a method therefor.
Koenig Hans
Massie Bernard
National Research Council Of Canada
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