Adenovirus e1b-55k single amino acid mutants and methods of use

Details Adenovirus e1b-55k single amino acid mutants and methods of use Adenovirus e1b-55k single amino acid mutants and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 35/76 (2006.01) A61K 38/16 (2006.01) C07K 14/075 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2415333

Adenoviral mutants are described that have single amino acid mutations in the E1B-55K protein which mutations effect the p53 binding/inactivation and the late functions of the E1B-55K protein in a manner that enhances the efficacy of such viruses for treating cancer when compared to adenoviral mutants that have the E1B-55K region deleted.

L'invention concerne des mutants adénoviraux ayant des mutations d'acide aminé unique dans la protéine E1B-55K. Ces mutations modifient la liaison/l'inactivation de p53 et les fonctions tardives de la protéine E1B-55K d'une manière qui augmente l'efficacité de virus destinés au traitement du cancer par rapport à des mutants adénoviraux dont la région E1B-55K est délétée.

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