Adenovirus-mediated gene transfer to cardiac and vascular...

Details Adenovirus-mediated gene transfer to cardiac and vascular... Adenovirus-mediated gene transfer to cardiac and vascular...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61P 9/10 (2006.01) C07K 14/47 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2149771

2149771 9411506 PCTABS00032 The present invention relates to the use of adenovirus-mediated gene transfer to regulate function in cardiac and vascular smooth muscle cells. A recombinant adenovirus comprising a DNA sequence that codes for a gene product is delivered to a cardiac or vascular smooth muscle cell and the cell is maintained until that gene product is expressed. Delivery is direct injection into a muscle cell or infusing a pharmaceutical composition containing an adenovirus vector construct intravascularly.

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