Adenovirus vector

Details Adenovirus vector Adenovirus vector

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2488058

This invention relates to an adenovirus vector having excellent gene transfection activity on specific cell lines, particularly on hematopoietic cells. This adenovirus vector derives from the adenovirus type 35 genome by at least partial or total deletion of the E1 region therefrom. The adenovirus vector according to this invention has excellent gene transfection activity on specific cell lines, particularly on hematopoietic cells, ES cells, pluripotent stem cells, blood stem cells, and tissue stem cells.

La présente invention concerne un vecteur d'adénovirus qui contient au moins un génome d'adénovirus de type 35 complètement ou partiellement dépourvu de E1 et qui présente une très bonne activité de transfert de gène sur des lignées cellulaires spécifiques, notamment sur des cellules hématopoïétiques, des cellules ES, des cellules souches multipotentes, des cellules souches sanguines et des cellules souches tissulaires.

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