Adenovirus vectors comprising introns

Details Adenovirus vectors comprising introns Adenovirus vectors comprising introns

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 15/861 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2415347

The invention disclosed herein provides adenovirus vectors comprising introns 5' to transgenes. Such adenovirus vectors are useful for expression of proteins. Methods of making and using these adenovirus vectors are provided herein. In particular, methods of obtaining increased expression of viral proteins from the adenovirus vectors comprising introns 5' to transgenes is provided.

L'invention concerne des vecteurs adénoviraux comprenant des introns 5' par rapport aux transgènes. De tels vecteurs adénoviraux sont utiles dans l'expression de protéines. L'invention concerne également des procédés de fabrication et d'utilisation de ces vecteurs adénoviraux. Plus spécifiquement, l'invention concerne des procédés permettant d'obtenir une expression augmentée des protéines virales à partir des vecteurs adénoviraux comprenant des introns 5' par rapport aux transgènes.

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