Adenovirus vectors containing cell status-specific response...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2343135

The present invention provides adenoviral vectors comprising cell status- specific transcriptional regulatory elements which confer cell status-specific transcriptional regulation on an adenoviral gene. A "cell status" is generally a reversible physiological and/or environmental state. The invention further provides compositions and host cells comprising the vectors, as well as methods of using the vectors.

La présente invention concerne des vecteurs d'adénovirus qui contiennent des éléments de régulation transcriptionnelle spécifiques de l'état des cellules conférant à un gène adénoviral une régulation transcriptionnelle spécifique de l'état des cellules. Un "état des cellules" est généralement un état physiologique et/ou environnemental réversible. L'invention concerne en outre des compositions et des cellules hôtes contenant lesdits vecteurs, ainsi que des procédés d'utilisation desdits vecteurs.

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