Adenovirus vectors for gene therapy

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/861 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2226833

The present invention relates to novel adenovirus vectors for use in gene therapy which are designed to prevent the generation of replication-competent adenovirus (RCA) during in vitro propagation and clinical use. The invention also provides methods for the production of the novel virus vectors. These vectors maximize safety for clinical applications in which adenovirus vectors are used to transfer genes into recipient cells for gene therapy.

La présente invention se rapporte à de nouveaux vecteurs d'adénovirus qui sont utilisés dans la thérapie génique et qui sont conçus pour empêcher la génération d'adénovirus capables de se répliquer (RCA) pendant la propagation in vitro et l'utilisation clinique. L'invention décrit également des méthodes de production de nouveaux vecteurs de virus. Ces vecteurs maximisent la sécurité concernant les applications cliniques dans lesquelles les vecteurs d'adénovirus sont utilisés pour transférer des gènes dans des cellules receveuses pour la thérapie génique.

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