Adenovirus vectors for gene therapy

Details Adenovirus vectors for gene therapy Adenovirus vectors for gene therapy

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2166118

The invention comprises a series of adenovirus-based vectors having deletions in the E1 and/or E3 regions, and optionally insertions of pBR322 sequences, which can be used to deliver nucleic acid inserts into host cells, tissues or organisms that then can express the insert. The invention also comprises the use of these vectors in introducing genes into cells, in making vaccines and in gene therapy.

L'invention porte sur une série de vecteurs à base d'adénovirus, comportant des délétions dans les régions E1 et/ou E3, et éventuellement des insertions de séquences pBR322, qu'on peut utiliser pour délivrer des inserts d'acide nucléique dans des cellules hôtes, tissus ou organismes qui peuvent alors exprimer l'insert. L'invention concerne aussi l'utilisation de ces vecteurs pour introduire des gènes dans les cellules, pour fabriquer des vaccins, et pour la thérapie génique.

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