Adenovirus vectors for the transfer of foreign genes into...

Details Adenovirus vectors for the transfer of foreign genes into... Adenovirus vectors for the transfer of foreign genes into...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A01K 67/027 (2006.01) A61K 38/18 (2006.01) A61K 38/44 (2006.01) A61K 38/47 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 9/04 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/52 (2006.01) C12N 15/86 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2145535

The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression and/or transcription of a selected nucleotide sequence in the cells of the central nervous system and in that it comprises (i) at least part of the genome of an adenovirus, including the regions required for that adenovirus to penetrate into the cells normally infectable by that adenovirus and (ii) being inserted into said part of genome of an adenovirus under the control of a promoter, either present or also inserted into said genome part and operative in said cells. This recombinant vector finds particular use in the treatment of diseases of the central nervous system, also in gene therapy.

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