Adenovirus vectors specific for cells expressing...

Details Adenovirus vectors specific for cells expressing... Adenovirus vectors specific for cells expressing...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 7/00 (2006.01) C12N 15/34 (2006.01)

Patent

CA 2282706

Adenovirus vectors replication specific for cells expressing .alpha.- fetoprotein (AFP) and their methods of use are provided. By providing for a transcriptional initiating regulation dependent upon AFP expression, virus replication is restricted to target cells expressing AFP, particularly hepatocellular carcinoma cells. The adenovirus vectors can be used to detect and monitor samples for the presence of AFP-producing cells as well as to kill selectively malignant cells producing AFP.

L'invention porte sur la réplication de vecteurs d'adénovirus spécifiques de cellules exprimant la fétoprotéine alpha (AFP) et leurs modes d'utilisation. En faisant dépendre la régulation du déclenchement de la transcription de l'expression de l'AFP, on limite la réplication des virus aux cellules cibles exprimant l'AFP et en particulier aux cellules des carcinomes hépatocellulaires. Les vecteurs d'adénovirus peuvent servir à détecter et suivre les échantillons pour ce qui est de la présence des cellules génératrices d'AFP, et à tuer sélectivement les cellules malignes génératrices d'AFP.

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