Adenovirus vectors with knobless fibers, and their uses

Details Adenovirus vectors with knobless fibers, and their uses Adenovirus vectors with knobless fibers, and their uses

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) C07K 14/075 (2006.01) C07K 14/15 (2006.01) C12N 15/10 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2407518

The present invention provides novel adenoviral vectors, in which the knob of the fiber protein has been removed and replaced with a binding ligand. The invention also provides methods of constructing such vectors and provides uses for such vectors. A modified knobless adenovirus comprising a new binding ligand according to the invention has improved capabilities of entry into specific cell types.

L'invention concerne de nouveaux vecteurs adénoviraux, dans lesquels la spicule de la protéine fibreuse a été éliminée et remplacée par un ligand. L'invention concerne également des procédés de construction de tels vecteurs et des utilisations de ces derniers. Un adénovirus sans spicule modifié comprenant un nouveau ligand de l'invention présente de meilleures capacités d'introduction dans des types de cellules spécifiques.

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