Adenovirus with mutations in the endoplasmic reticulum...

Details Adenovirus with mutations in the endoplasmic reticulum... Adenovirus with mutations in the endoplasmic reticulum...

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 35/76 (2006.01)

Patent

CA 2680659

The present invention relates to an adenovirus wherein said adenovirus replicates and it contains a mutation in the endoplasmic reticulum retention domain of E3-19K, and to the use of said mutant in treating cancer. Said mutant virus may also contain other mutations and insertions of DNA sequences used to confer selectivity and antitumor potency. The invention has application in the field of cancer therapy.

La présente invention concerne un adénovirus, ledit adénovirus se reproduisant et contenant une mutation dans le domaine de rétention du réticulum endoplasmique d'E3-19K. L'invention concerne également l'utilisation dudit mutant dans le traitement du cancer. Ledit virus mutant peut en outre contenir d'autres mutations et insertions de séquences d'ADN utilisées pour conférer une sélectivité et une activité anti-tumorale. Enfin, l'invention porte sur des applications dans le domaine de la thérapie cancéreuse.

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