Adenoviruses having modified fiber proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C07K 14/475 (2006.01) C07K 14/525 (2006.01) C07K 14/775 (2006.01) C12N 7/04 (2006.01) C12N 9/64 (2006.01) C12N 15/861 (2006.01) C12N 15/87 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2161136

An adenovirus wherein the adenovirus fiber protein includes a ligand which is specific for a receptor located on a desired cell type. The adenovirus may have at least a portion of the adenovirus fiber protein removed and replaced with a ligand which is specific for a receptor located on a desired cell type, or the adenovirus may include a fusion protein of the adenovirus fiber protein and the ligand. Such an adenovirus may also include a gene(s) encoding a therapeutic agent(s) and may be "targeted" in order to deliver such gene(s) to a desired cell type.

Adénovirus dans lequel la protéine fibreuse comprend un ligand qui est spécifique contre un récepteur situé sur un type de cellule désirée. L'adénovirus peut être tel qu'au moins une partie de sa protéine fibreuse est éliminée et remplacée par un ligand qui est spécifique contre un récepteur situé sur un type de cellule désirée, ou bien l'adénovirus peut comprendre une protéine de fusion issue de la fusion de la protéine fibreuse de l'adénovirus et du ligand. Cet adénovirus peut également comporter un ou plusieurs gènes qui codent un ou plusieurs agents thérapeutiques et qui peuvent être "ciblés" afin d'apporter ce ou ces gènes à un type de cellule désiré.

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