Adherent entities and uses therefor

Details Adherent entities and uses therefor Adherent entities and uses therefor

G - Physics

01

N

G01N 33/569 (2006.01) A01K 67/00 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) A61P 15/08 (2006.01) C07K 14/195 (2006.01) C07K 14/30 (2006.01) C07K 16/12 (2006.01) C12N 15/31 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2447215

The present invention is directed to reproductive function-modulating organisms especially of the genera Ureaplasma and Mycoplasma, which adhere more strongly to spermatozoa than other organisms and which correlate with the presence or risk of a condition selected from male infertility, an adverse pregnancy outcome or an adverse assisted reproductive technology outcome. More particularly, the invention is directed to the detection of these reproductive function-modulating organisms (also referred to herein as adherovars), and to various therapeutic and prophylactic strategies for enhancing or otherwise improving inter alia fertility and especially male fertility.

L'invention concerne des organismes modulant la fonction reproductive, des genres Ureaplasma et Mycoplasma, qui adhèrent plus fortement aux spermatozoïdes que d'autres organismes et qui sont corrélés à la présence ou au risque d'un état, tel que l'infertilité masculine, une issue défavorable de la grossesse ou une issue défavorable d'un acte technique de reproduction assistée. L'invention porte notamment sur la détection desdits organismes modulant la fonction reproductrice (également appelés ici adherovars) et sur diverses stratégies thérapeutiques et prophylactiques pour améliorer ou augmenter, entre autres, la fertilité et notamment la fertilité masculine.

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