A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/108 (2006.01)
Patent
CA 2592444
The inventive subject matter relates to the methods for the induction of immunity and prevention of diarrhea resulting from Escherichia coli. The inventive subject matter also relates to the use Escherichia coli adhesins as immunogens and to the construction of conformationally stability and protease resistant Escherichia coli adhesin constructs useful for inducing immunity to Escherichia coli pathogenic bacteria. The methods provide for the induction of B-cell mediated immunity and for the induction of antibody capable of inhibiting the adherence and colonization of Escherichia.coli, including. enterotoxigenic Escherichia coli, to human cells.
L'invention concerne des procédés assurant une immunisation et une prévention pour la diarrhée provoquée par l'Escherichia coli, ainsi que l'utilisation d'adhésines de l'Escherichia colicomme immunogènes, et la réalisation de constructions d'adhésine d'Escherichia coli, à stabilité de conformation et résistance à la protéase, utiles pour induire une immunisation vis-à-vis des bactéries pathogènes de l'Escherichia coli. Les procédés décrits consistent à induire une immunité à médiation assurée par les lymphocytes B et à induire des anticorps capables d'inhiber l'adhérence et la colonisation de l'Escherichia coli, y compris l'Escherichia coli. entérotoxigène, sur le terrain des cellules humaines.
Bennett Jones Llp
The United States Of America As Represented By The Secretary Of
LandOfFree
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