Adhesin-enterotoxin chimera based immunogenic composition...

A - Human Necessities – 61 – K

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A61K 39/108 (2006.01)

Patent

CA 2635409

The inventive subject matter relates to an immunogenic composition composed of a chimeric molecule including a conformationally stable adhesin from Escherichia coli fused to a bacterial toxin A subunit, such as cholera toxin A subunit or heat-labile Escherichia coli toxin A subunit. The invention also relates to the adhesin-toxin chimera noncovalently associated with a toxin B subunit of the same or different species as the A subunit. The invention also relates to a method of utilizing an adhesin/toxin fusion composition to elicit an immune response.

L'invention concerne une composition immunogénique composée d'une molécule chimérique comprenant une adhésine de conformation stable d'Escherichia coli fusionnée à une sous-unité A de toxine bactérienne, telle qu'une sous-unité A de la toxine du choléra ou une sous-unité A de la toxine thermolabile d'Escherichia coli. L'invention concerne aussi la chimère avec l'adhésine-toxine associée de façon non covalente avec une sous-unité B de toxine de la même espèce ou d'une espèce différente de la sous-unité A. L'invention concerne aussi une méthode pour utiliser une composition de la fusion adhésine/toxine pour produire une réponse immunitaire.

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