Adhesion inhibitors, preparation comprising them and method...

Details Adhesion inhibitors, preparation comprising them and method... Adhesion inhibitors, preparation comprising them and method...

A - Human Necessities

61

K

A61K 35/74 (2006.01) C12P 19/04 (2006.01) C12P 19/26 (2006.01)

Patent

CA 2243067

Products for inhibiting the adhesion of pathogens to gastrointestinal epithelial mucosa in animals including humans are described. The products contain high molecular weight carbohydrates produced by Lactobacillus strains of enteric origin preferably having a composition of N-acetylglucose- amine:galactose:glucose in a ratio of 1:3:2. There is also described preparations for oral administration comprising as active ingredient the products above, when purified, partially purified, or modified chemically while retaining the biological activity, as well as subunits and complexes thereof which retain the biological activity, or Lactobacillus strains producing the products, or culture supernatant resulting from culturing Lactobacillus strains producing the products. Further, there is described a method of preparation of the products by culturing Lactobacillus strains producing the products.

Produits destinés à inhiber l'adhésion d'agents pathogènes sur la muqueuse épithéliale gastro-intestinale chez les êtres vivants, notamment chez l'homme. Ces produits renferment des hydrates de carbone à poids moléculaire élevé obtenus à partir de souches de lactobacillus d'origine entérique présentant de préférence une composition de N-acétylglucose-amine:galactose:glucose sous un rapport de 1:3:2. L'invention porte également sur des préparations pour administration orale comprenant comme principe actif les produits précités conservant leur activité biologique après avoir été purifiés, partiellement purifiés ou modifiés chimiquement, ainsi que sur des sous-unités ou des complexes de celles-ci conservant leur activité biologique, ou sur des souches de lactobacillus donnant ces produits, ou encore sur un supernatant de culture résultant de la culture de souches de lactobacillus donnant ces produits. L'invention porte enfin sur un procédé de préparation de ces produits par culture de souches de lactobacillus donnant ces produits.

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