Adhesion receptors for pathogenic or opportunistic...

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Patent

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G01N 33/569 (2006.01) C07H 3/06 (2006.01) C07H 15/10 (2006.01) C07K 14/195 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2095642

Disclosed herein are receptors for pathogenic or opportunistic microorganisms, methods of obtaining such receptors, and methods of using such receptors for diagnostic or pharmaceutical purposes. The receptor comprises a substantially pure compound selected from the group consisting of GalB1-4GlcNAcB1-3GalB1-4GlcB1- 1-X(R), GalB1-3GlcNAcB1-3GalB1-4GlcB1-1-X(R); GlcNAcB1-3GalB1-4GlcB1-1-X(R), GalB1- 4GlcNAcB1-3GalB1-4Glc, GalB1-3GlcNAcB1-3GalB1-4Glc, GlcNAcB1-3GalB1-4Glc, GalB1-4GlcNAcB1-3Gal, and GalB1-3-GlcNAcB1-3Gal wherein X is sphingosine, hydroxylated sphingosine, or saturated sphingosine and R is H or an N-acyl fatty acid derivative of X such that X(R) is a ceramide. The invention further comprises proteins and polypeptides that bind to the receptors, methods of obtaining such proteins or polypeptides from natural sources or through recombinant DNA techniques, and methods of using the purified proteins and polypeptides for pharmaceutical and diagnostic purposes, preferably in a vaccine for administration to an animal or human host to protect against pathogenic or opportunistic microorganisms.

L'invention décrit des récepteurs de micro-organismes pathogènes ou opportunistes, des procédés d'obtention desdits récepteurs et des procédés d'utilisation desdits récepteurs dans un but pharmaceutique ou diagnostique. Le récepteur comprend un composé pratiquement pur, selectionné à partir du groupe constitué par: GalB1-4GlcNAcB1-3GalB1-4GlcB1-1-X(R), GalB1-3GlcNAcB1-3GalB1-4GlcB1-1-X(R), GlcNAcB1-3GalB1-4GlcB1-1-X(R), GalB1-4GlcNAcB1-3GalB1-4Glc, GalB1-3GlcNAcB1-3GalB1-4Glc, GlcNAcB1, 3GalB1-4Glc, GalB1-4GlcNAcB1-3Gal, et GalB1-3-GlcNAcB1-3Gal, dans lequel X représente sphingosine, sphingosine hydroxylée ou sphingosine saturée et R représente H ou un dérivé de X d'acide gras N-acyle, de façon que X(R) représente un céramide. L'invention comprend, de plus, des protéines et des polypeptides se liant aux récepteurs, des procédés d'obtention desdites protéines ou desdits polypeptides à partir de sources naturelles ou au moyen de techniques d'ADN recombinant, ainsi que des procédés d'utilisation des protéines et des polypeptides purifiés dans un but pharmaceutique et diagnostique, de préférence, dans un vaccin à administrer à l'homme ou à l'animal en tant que protection contre des micro-organismes pathogènes ou opportunistes.

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