Adhesive pharmaceutical preparation

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61K 47/10 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2633027

In the adhesive pharmaceutical preparation of the invention, a pressure- sensitive adhesive layer is laminated on one side of the backing. The pressure-sensitive adhesive layer contains a branched monoalcohol having from 12 to 28 carbon atoms, a drug which is liquid at room temperature or around room temperature (in which, free base of bisoprolol is excluded) and a polyisobutylene pressure-sensitive adhesive. Accordingly, compatibility of the polyisobutylene pressure-sensitive adhesive with the drug can be specifically increased. As a result, not only it becomes possible to increase blending amount of the drug but also bleed of the drug from the pressure- sensitive adhesive layer can be suppressed and, what is more, the pressure-sensitive adhesion characteristics sufficient from the practical point of view can be obtained.

La présente invention se rapporte à une préparation adhésive, qui comprend un support et une couche adhésive disposée sur une surface dudit support. La couche adhésive est caractérisée en ce qu'elle contient un alcool monohydrique ramifié possédant de 12 à 28 atomes de carbone, un médicament à l'état liquide à température ambiante ou à une température proche de la température ambiante (à l'exclusion d'une base libre de bisoprolol), et un adhésif à base de polyisobutylène. Ladite structure peut en particulier améliorer la compatibilité entre l'adhésif à base de polyisobutylène et le médicament, ce qui augmente le taux de mélange du médicament, élimine la migration du médicament de la couche adhésive, et permet d'obtenir une propriété adhésive suffisante du point de vue pratique.

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