Adhesive pharmaceutical preparation containing bisoprolol

Details Adhesive pharmaceutical preparation containing bisoprolol Adhesive pharmaceutical preparation containing bisoprolol

A - Human Necessities

61

K

A61K 31/138 (2006.01) A61K 9/70 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/32 (2006.01) A61P 9/06 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2621867

It is intended to provide an adhesive preparation which has a low irritation to the skin surface, is excellent in stability of bisoprolol in the preparation and further is capable of continuously administrating a pharmacologically effective amount of bisoprolol to the living body. The adhesive preparation (10) has a support (1) and an adhesive layer (2) which is layered on one surface of the support (1). The adhesive layer (2) is characterized by containing bisoprolol, polyisobutylene, a tackifier and an organic liquid component which is compatible with polyisobutylene and the tackifier. By this, the adhesive preparation having good skin adhesiveness, low skin irritation and reduced pain or adhesive residue at the time of removal from the skin surface can be provided. Further, the adhesive preparation in which the stability of bisoprolol in the adhesive preparation is excellent and the pharmacologically effective amount of bisoprolol can be continuously administrated to the living body through the skin surface is provided.

L~invention concerne une préparation adhésive qui présente une faible irritation de la surface de la peau, est excellente en terme de stabilité du bisoprolol dans la préparation et est en outre capable d'administrer en continu une quantité pharmacologiquement efficace de bisoprolol au corps vivant. La préparation adhésive (10) comprend un support (1) et une couche adhésive (2) qui est couchée sur une surface du support (1). La couche adhésive (2) est caractérisée en ce qu'elle contient du bisoprolol, du polyisobutylène, un agent poisseux et un composant liquide organique qui est compatible avec le polyisobutylène et l'agent poisseux. De cette manière, l~invention concerne la préparation adhésive ayant une bonne adhésivité sur la peau, une faible irritation de la peau et une douleur ou un résidu adhésif réduits lorsqu~on l'enlève de la surface de la peau. De plus, l~invention concerne la préparation adhésive dans laquelle la stabilité du bisoprolol est excellente et la quantité pharmacologiquement efficace de bisoprolol peut être administrée en continu au corps vivant à travers la surface de la peau.

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