Adhesives resistant to skin-penetration enhancers

Details Adhesives resistant to skin-penetration enhancers Adhesives resistant to skin-penetration enhancers

C - Chemistry, Metallurgy

08

F

C08F 291/00 (2006.01) A61K 9/70 (2006.01) A61L 15/58 (2006.01) A61M 37/00 (2006.01) C08G 18/28 (2006.01) C08G 18/60 (2006.01) C08G 18/62 (2006.01) C08G 18/64 (2006.01) C08G 18/72 (2006.01)

Patent

CA 2195336

A graft copolymer for use as an adhesive for drug delivery patches or dressings that is resistant to dissolution in the presence of skin penetration enhancers comprises copolymerized acrylic and, optionally, vinyl monomers, to form a backbone polymer, to which are grafted polymeric moieties that do not absorb greater than 3% by weight of a skin- penetration enhancer under thermodynamic equilibrium at 25°C if independently introduced into an excess of the enhancer. Preferably, the grafted polymers are selected from the classes of polybutylene, polysaccharide, poly(ethyleneoxide/propyleneoxide), and polyamide polymers, and specific grafted polymers will depend on the specific enhancers used in a particular drug delivery system.

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