Adipocyte differentiation-related gene and protein

Details Adipocyte differentiation-related gene and protein Adipocyte differentiation-related gene and protein

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 37/00 (2006.01)

Patent

CA 2469524

Polynucleotides which are produced by preadipocytes within 12 hours from the start of adipocyte differentiation induction and comprise a base sequence identical or at least 93% homologous to SEQ ID NO:1, or a base sequence identical to SEQ ID NO:9, or polynucleotides complementary to those polynucleotides, and proteins comprising an amino acid sequence identical or at least 96% homologous to the protein shown under SEQ ID NO:2 or comprising the amino acid sequence shown under SEQ ID NO:10 are provided.

L'invention se rapporte à un polynucléotide produit par des adipocytes précurseurs en 12 heures (en particulier en l'espace d'environ 6 heures), après l'initiation de l'induction de la différenciation adipocytaire, et présentant au moins une identité de 93 % avec SEQ ID NO:1 et la même séquence de bases que SEQ ID NO:9 ; ou à un polynucléotide complémentaire à ce polynucléotide. L'invention concerne également une protéine présentant la même séquence que la protéine non clivée représentée par SEQ ID NO:2 ou au moins une identité de 96 % avec celle-ci, ou la séquence d'acides aminés représentée par SEQ ID NO:10.

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