C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7105 (2006.01)
Patent
CA 2667971
The present invention is directed to constructs, compositions and methods for modulating platelet-type 12 lipoxygenase (12-LO) in adipose tissue in vivo. Specifically, the invention provides constructs encoding expression-inhibiting oligonucleic acids, e.g. antisense and RNA interfering (RNAi) molecules, targeted to a platelet-type 12-LO gene or a transcript thereof, which are capable of reducing or silencing platelet-type 12-LO expression specifically in adipocytes and pre-adipocytes. Vectors comprising these constructs (including, but not limited to, viral vectors), compositions comprising them and methods of using same for the treatment and amelioration of conditions associated with excess fat cell mass and obesity are also provided.
L'objet de la présente invention concerne des constructions, compositions et procédés destinés à moduler in vivo la 12-lipoxygénase de type plaquette (12-LO) dans le tissu adipeux. L'invention fournit en particulier des constructions de codage d'acides oligonucléiques inhibiteurs d'expression, par exemple des molécules antisens et des molécules interférant avec l'ARN (RNAi) ciblées sur un gène de plaquette type 12-LO ou bien sur son transcrit, et capables de réduire ou de bloquer l'expression de plaquette de type 12-LO uniquement sur les adipocytes et les pré-adipocytes. L'invention concerne également les vecteurs qui contiennent ces constructions (au nombre desquels, mais pas uniquement, les vecteurs viraux), les compositions qui les contiennent et les procédés les utilisant en vue de traiter et d'améliorer les conditions associées à l'excès de masse de cellules adipeuses et à l'obésité.
Limor Rona
Stern Naftali
Weisinger Gary
Ridout & Maybee Llp
The Medical Research Fund At The Tel-Aviv Sourasky Medical Cente
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