Adipocyte-specific differentiation-related protein

Details Adipocyte-specific differentiation-related protein Adipocyte-specific differentiation-related protein

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2274728

The present invention provides a human adipocyte-specific differentiation- related protein (HADRP) and polynucleotides which identify and encode HADRP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HADRP and a method for producing HADRP. The invention also provides for agonists, antibodies, or antagonists specifically binding HADRP, and their use, in the prevention and treatment of diseases associated with expression of HADRP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HADRP for the treatment of diseases associated with the expression of HADRP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HADRP.

La présente invention a trait à une protéine humaine liée à la différentiation spécifique de l'adipocyte (HADRP) et aux polynucléotides identifiant et codant la protéine HADRP. L'invention fournit aussi des vecteurs d'expression génétique et des cellules hôtes comprenant les séquences nucléotidiques codant la protéine HADRP et une méthode de production d'HADRP. L'invention se rapporte aux agonistes, anticorps ou antagonistes liant la protéine HADRP, et leur utilisation, dans la prévention et le traitement des maladies associées à l'expression de la protéine HADRP. Par ailleurs, l'invention porte sur l'utilisation des molécules antisens aux polynucléotides codant la protéine HADRP pour le traitement des maladies associées à l'expression d'HADRP. Les méthodes diagnostiques, qui utilisent le polynucléotide, ou fragments ou complément, et les anticorps spécifiquement liés à la protéine HADRP, font aussi l'objet de cette invention.

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