Adiponectin antibodies and methods to measure adiponectin

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) C07K 16/26 (2006.01) G01N 33/74 (2006.01) C07K 14/575 (2006.01)

Patent

CA 2673961

The invention pertains to methods for measuring different forms of human adiponectin that are present in human plasma/serum, and more specifically methods are based on an ELISA assay that utilizes different monoclonal antibodies directed against adiponectin, in combination with different polyclonal antibodies directed against different domains of human adiponectin. The invention also provides unique isoforms of adiponectin and antibodies thereto, including polyclonal and monoclonal antibodies.

L'invention concerne des procédés pour mesurer différentes formes de l'adiponectine humaine qui sont présentes dans le plasma/sérum humain, et, plus spécifiquement, des procédés qui sont basés sur un test ELISA qui utilise différents anticorps monoclonaux dirigés contre l'adiponectine, en combinaison avec différents anticorps polyclonaux dirigés contre différents domaines de l'adiponectine humaine. L'invention concerne également des isoformes uniques d'adiponectine et des anticorps dirigés contre celle-ci, comprenant des anticorps polyclonaux et monoclonaux.

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