Adiponectin fragments and conjugates

Details Adiponectin fragments and conjugates Adiponectin fragments and conjugates

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 33/06 (2006.01) A61K 38/22 (2006.01) A61K 47/02 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2468619

The invention relates to a conjugate comprising an adiponectin polypeptide, and a first non-polypeptide moiety covalently attached to the adiponectin polypeptide, wherein the adiponectin polypeptide comprises an amino acid residue having an attachment group for said first non-polypeptide moiety, wherein said amino acid residue has been introduced in a position that in the parent adiponectin is occupied by a surface exposed amino acid residue. The non-polypeptide moiety may be a polymer, e.g. PEG. Further described is an isolated complex comprising an adiponectin trimer and calcium ions. The conjugate or complex is used in the treatment of disorders such as type 2 diabetes, cardiovascular disease and septic shock.

L'invention concerne un conjugué comprenant un polypeptide de l'adiponectine, et une première fraction non polypeptidique liée de manière covalente au polypeptide de l'adiponectine. Le polypeptide de l'adiponectine comprend un résidu d'amino-acide ayant un groupe de fixation pour la première fraction non polypeptidique. Ledit résidu d'amino-acide a été introduit dans une position qui, dans l'adiponectine parent, est occupée par un résidu d'amino-acide exposé en surface.

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