Adipose derived adult stromal cells exhibiting...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/02 (2006.01) C12N 5/00 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2596281

The present invention encompasses an adipose-derived adult stromal (ADAS) cell exhibiting at least one characteristic of a pre-endothelial cell and/or an endothelial cell. The present invention also encompasses compositions and methods for generating an adipose-derived adult stromal to exhibit at least one characteristic of a pre-endothelial cell and/or an endothelial cell. Methods for using the cells in vascular transplantation, tissue engineering, regulation of angiogenesis, vasculogenesis, and the treatment of numerous disorders including heart disease are also included.

L'invention se rapporte à une cellule stromale adulte dérivée du tissu adipeux (ADAS), présentant au moins une caractéristique d'une cellule pré-endothéliale et/ou d'une cellule endothéliale. L'invention concerne également des compositions et des méthodes permettant de produire des cellules stromales adultes dérivées du tissu adipeux, présentant au moins une caractéristique d'une cellule pré-endothéliale et/ou d'une cellule endothéliale. L'invention concerne en outre des méthodes d'utilisation de ces cellules pour les greffes vasculaires, le génie tissulaire, la régulation de l'angiogenèse, la vasculogenèse, et pour le traitement d'un grand nombre de troubles comprenant notamment les cardiopathies.

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