Adir related polymorphisms and applications thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/475 (2006.01) A61K 38/00 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2638822

The invention relates to the field of stem cell transplantations, immunotherapy and prophylaxis of neoplastic disease. Provided are peptides comprising an amino acid sequence encoded by an open reading frame as present in the nucleotide sequence of a transcript of a naturally occurring hADIR allele, wherein the amino acid sequence comprises a polymorphic MHC class I or II minor histocompatibility binding peptide.

La présente invention concerne de domaine des transplantations de cellules souches, de l'immunothérapie et de la prophylaxie des maladies néoplasiques. On décrit des peptides comprenant une séquence d'acides aminés codée par un cadre de lecture ouvert tel qu'il se trouve dans la séquence nucléotidique d'un transcrit d'un allèle hADIR d'origine naturelle, ladite séquence d'acides aminés comprenant un peptide de liaison mineur d'histocompatibilité de classe I ou II MHC polymorphe.

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