Adjuvant activity through modulation of animal and plant...

Details Adjuvant activity through modulation of animal and plant... Adjuvant activity through modulation of animal and plant...

C - Chemistry, Metallurgy

12

Q

C12Q 1/42 (2006.01) C12Q 1/00 (2006.01) C12Q 1/34 (2006.01)

Patent

CA 2373424

The present invention relates to the modulation of pesticidal and herbicidal activity by treatment of a membrane transport system in a cell. This entails modifying the extra-cellular phosphatases found in the membranes of these cells. By modifying the ATP gradient across the biological membrane of a target plant, bacteria, insect or mammalian cell via inhibiting one or more extra-cellular phosphatases, it is possible to alter the sensitivity to a pesticide or herbicide. In preferred embodiments, the chemical moieties of the invention act as adjuvants to enhance pesticidal activity.

L'invention concerne la modulation de l'activité des pesticides et des herbicides par le traitement du système de transport membranaire dans une cellule. Ceci rend nécessaire la modification des phosphatases extracellulaires qui se trouvent dans les membranes de ces cellules. En modifiant le gradient d'ATP à travers la membrane biologique d'une cellule cible d'une plante, d'une bactérie, d'un insecte ou d'un mammifère par l'inhibition d'une ou de plusieurs phosphatases extracellulaires, il est possible de modifier sa sensibilité envers un pesticide ou un herbicide. Dans des modes de réalisation préférés, les groupes fonctionnels chimiques de l'invention agissent en tant qu'adjuvants pour augmenter l'activité du pesticide.

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