Adjuvant and cell maturation agent

Details Adjuvant and cell maturation agent Adjuvant and cell maturation agent

A - Human Necessities

61

K

A61K 39/39 (2006.01) C07K 14/705 (2006.01) C12N 5/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2362783

Use of CD38, or a portion thereof or analogue thereof which can inhibit the binding of CD38 to a non-follicular dendritic cell (DC) or a follicular dendritic cell (FDC) and which retains the ability of CD38 to stimulate a DC or FDC, for use in the manufacture of an adjuvant for use in immunotherapy. Also provided is a method of maturing DCs in vitro and a vaccine comprising mature DCs. The invention also provides a natural ligand of CD38 on FDCs and DCs and inhibitors of the ligand. The inhibitors can be used for immunosuppression.

L'invention concerne l'utilisation d'une cellule CD38, d'une partie de celle-ci, ou d'un analogue pouvant inhiber la liaison de CD38 avec une cellule dendritique (DC) non folliculaire ou une cellule dendritique folliculaire (FDC), et maintenir la capacité de CD38 à stimuler une DC ou une FDC, afin de produire un adjuvant utilisé en immunothérapie. L'invention concerne également un procédé de maturation des DC in vitro, et un vaccin comprenant ces DC matures. L'invention concerne, en outre, un ligand naturel de CD38 présent sur une FDC et une DC, et des inhibiteurs de ce ligand. Ces inhibiteurs peuvent être utilisés dans l'immunodépression.

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