A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/095 (2006.01) A61K 39/155 (2006.01) A61K 39/21 (2006.01) A61K 39/35 (2006.01)
Patent
CA 2372181
The use of 3-O-deacylated monophosphoryl lipid A or monophosphoryl lipid A and derivatives and analogs thereof, in combination with a cytokine or lymphokine such as granulocyte macrophage colony stimulating factor or interleukin-12 is useful as an adjuvant combination in an antigenic composition to enhance the immune response in a vertebrate host to a selected antigen.
L'invention concerne un monophosphoryl lipide A 3-0-désacétylé ou un monophosphoryl lipide A et des dérivés et analogues de ceux-ci, utilisés en combinaison avec une cytokine ou une lymphokine, notamment un facteur stimulant les colonies de granulocytes macrophages ou l'interleukine-12. Cette préparation est utilisée comme combinaison d'adjuvants dans une composition antigénique afin d'améliorer, chez un vertébré, la réponse immunitaire à un antigène choisi.
American Cyanamid Company
Smart & Biggar
Wyeth Holdings Corporation
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