Adjuvant combinations comprising an nkt activator, a cd40...

Details Adjuvant combinations comprising an nkt activator, a cd40... Adjuvant combinations comprising an nkt activator, a cd40...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61P 37/04 (2006.01) A61K 48/00 (2006.01) C07H 15/10 (2006.01) C07K 14/705 (2006.01) C12N 1/11 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2685125

Adjuvant combinations comprising at least one NKT activator, such as alpha-galactosylceramide (.alpha.-Gal-Cer) or iGb3, a CD40 agonist and optionally an antigen are disclosed. The use of these immune adjuvants for treatment of various chronic diseases such as cancers is also provided.

La présente invention concerne des combinaisons adjuvantes comprenant au moins un activateur de NKT tel que l'alpha-galactosylcéramide (.alpha.-Gal-Cer) ou l'iGb3, un agoniste des CD40 et facultativement un antigène. L'invention concerne également l'utilisation des ces adjuvants immuns pour le traitement de diverses maladies chroniques telles que les cancers.

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