Adjuvant composition comprising aluminium phosphate and 3d-mpl

Details Adjuvant composition comprising aluminium phosphate and 3d-mpl Adjuvant composition comprising aluminium phosphate and 3d-mpl

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2598079

An immunogenic composition comprising: (i) an antigen; (ii) an aluminum phosphate adjuvant; and (iii) a 3-O-deacylated monophosphoryl lipid A adjuvant. Components (ii) and (iii) can also be used as a separate adjuvant system. Various features of the compositions are disclosed, including that at least 50 % of the 3-O-deacylated monophosphoryl lipid A adjuvant should be adsorbed to the aluminum phosphate adjuvant. The adjuvant mixture is particularly useful with hepatitis B virus surface antigen.

L'invention concerne une composition immunogénique renfermant: (i) un antigène; (ii) un adjuvant de phosphate d'aluminium; et (iii) un adjuvant de 3-O-déacylé monophosphoryl lipide A. Les composants (ii) et (iii) peuvent également être utilisés comme un système d'adjuvant distinct. L'invention concerne diverses caractéristiques des compositions, notamment le fait qu'au moins 50 % de l'adjuvant de 3-O-déacylé monophosphoryl lipide A devrait être adsorbé dans l'adjuvant de phosphate d'aluminium. Le mélange d'adjuvant est spécialement utile avec l'antigène de surface du virus de l'hépatite B.

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