A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61P 25/28 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2370697
The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. Methods of treating an individual susceptible to or suffering from a disease by the administration of the vaccines of the present invention are also provided.
Cette invention concerne des compositions d'adjuvant utilisables dans des vaccins. En particulier, lesdites compositions renferment une saponine et un oligonucléotide immunostimulatoire, éventuellement avec un excipient. La présente invention concerne également des vaccins renfermant lesdits adjuvants ainsi qu'un antigène. Sont également décrits des procédés de fabrication de ces adjuvants et de vaccins ainsi que leur utilisation en tant que médicaments. Enfin,l'invention concerne des méthodes de traitement, à l'aide desdits vaccins, d'individus prédisposés à une maladie ou atteint par cette maladie.
Friede Martin
Garcon Nathalie
Hermand Philippe
Borden Ladner Gervais Llp
Smithkline Beecham Biologicals S.a.
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