Adjuvant enhanced immunotherapy

A - Human Necessities – 61 – K

Patent

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A61K 38/20 (2006.01) A61K 31/525 (2006.01) A61K 31/704 (2006.01) A61K 38/19 (2006.01) A61K 38/21 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2482924

An improved method is provided for treating disease states characterized by the existence of pathogenic cell populations. In accordance with the improved method, cell-targeted ligand-immunogen or ligand-hapten complexes are administered to a diseased host to redirect the host immune response to the pathogenic cells which have an accessible binding site for the ligand. The method comprises the step of administering to the host a ligand-immunogen or ligand-hapten conjugate composition comprising a complex of the ligand and the immunogen or hapten wherein the immunogen/hapten is recognized by an endogenous antibody in the host or directly by an immune cell in the host. The improvement to the method comprises the step of using a T H 1-biasing adjuvant to enhance the immune response to cell-bound ligand-immunogen or ligan-hapten conjugates.

Cette invention se rapporte à un procédé amélioré servant à traiter des états pathologiques se caractérisant par l'existence de populations de cellules pathogènes. Selon ce procédé amélioré, des complexes ligand-immunogène ou ligand-haptène ciblés sur les cellules sont administrés à un organisme hôte malade afin de rediriger la réponse immunitaire de l'organisme hôte sur les cellules pathologiques ayant un site de fixation accessible pour le ligand. Ce procédé consiste à administrer à l'organisme hôte une composition de conjugué-immunogène ou ligand-haptène comprenant un complexe constitué par le ligand et l'immunogène ou l'haptène, l'immunogène/haptène étant reconnu par un anticorps endogène dans l'organisme hôte ou directement par une cellule immunitaire dans l'organisme hôte. L'amélioration apportée à ce procédé consiste à utiliser un adjuvant de sollicitation des cellules T<SB>H</SB>1 pour accroître la réponse immunitaire aux conjugués ligand-immunogène/ligand haptène fixés aux cellules.

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