Adjuvant for a vaccine composition

Details Adjuvant for a vaccine composition Adjuvant for a vaccine composition

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 9/127 (2006.01) A61K 39/145 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2205022

An amphipathic compound including a sterol-derived lipophilic grouping bound to a cationic grouping for use as an adjuvant in the delivery of a vaccine composition. In a particular embodiment, the lipophilic grouping is a cholesterol derivative and the cationic grouping is a quaternary ammonium or a protonatable amine. A vaccine composition including one or more antigens with at least one amphipathic compound having a sterol-derived lipophilic grouping bound to a cationic grouping, is also disclosed.

L'invention a pour objet un composé amphipathique comprenant un groupement lipophile dérivé d'un stérol lié à un groupement cationique pour son utilisation comme adjuvant dans l'administration d'une composition vaccinale. Selon un mode particulier, le groupement lipophile est un dérivé de cholestérol et le groupement cationique est un ammonium quaternaire ou une amine protonable. L'invention concerne aussi une composition vaccinale comprenant un ou plusieurs antigènes avec au moins un composé amphipathique possédant un groupement lipophile dérivé d'un stérol lié à un groupement cationique.

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