Adjuvant for vaccines comprising a hydrophobic sulfolipid...

Details Adjuvant for vaccines comprising a hydrophobic sulfolipid... Adjuvant for vaccines comprising a hydrophobic sulfolipid...

A - Human Necessities

61

K

A61K 39/39 (2006.01) C08B 37/16 (2006.01)

Patent

CA 2208790

Vaccine adjuvants comprising a sulpholipid polysaccharide in combination with an interface-forming constituent. The invention also provides a method for preparing a vaccine by emulsifying an aqueous solution of an antigen and a sulpholipid polysaccharide. The adjuvants are stable at high temperatures, and are at least as effective as conventional adjuvants. Their local toxicity, i.e. their reactogenicity, is generally lower than that of conventional adjuvants.

Adjuvants pour vaccins comprenant un polysaccharide sulfo-lipidique combiné à un composant formant une interface. On propose également un procédé pour préparer un vaccin en émulsionnant une solution aqueuse d'un antigène et un polysaccharide sulfo-lipidique. Les adjuvants proposés sont stables à haute température, leur efficacité est comparable ou même supérieure à celle des adjuvants classiques. Leur toxicité locale, c'est-à-dire leur réactogénicité est, en général, inférieure à celle des adjuvants classiques.

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