Adjuvant incorporation in immunonanotherapeutics

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01)

Patent

CA 2740155

The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.

L'invention concerne des compositions et des systèmes pour administrer des nanovéhicules à des cellules du système immunitaire. L'invention concerne des nanovéhicules capables de stimuler une réponse immunitaire dans des lymphocytes T et/ou dans des lymphocytes B. L'invention concerne des nanovéhicules qui comportent une surface présentant des caractéristiques immunitaires et une fraction immunostimulatoire. Dans certains modes de réalisation, le groupe immunostimulatoire est un adjuvant. L'invention concerne des compositions pharmaceutiques comportant des nanovéhicules de la présente invention. L'invention concerne des procédés de conception, de fabrication et d'utilisation des nanovéhicules de l'invention et des compositions pharmaceutiques de ceux-ci.

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