Adjuvant properties of poly(amidoamine) dendrimers

A - Human Necessities – 61 – K

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A61K 39/39 (2006.01) A61K 39/145 (2006.01)

Patent

CA 2249544

A new method of adjuvanting a variety of materials has been developed. Starburst dendrimers, primarily poly(amidoamine) starburst dendrimers, can be used as an adjuvant for Influenza antigen and similar materials. Mid- Generation dendrimers are preferred and yield high antibody titer levels with reduced antigen dosage.

Nouveau procédé permettant de créer un effet adjuvant pour toute une variété de matériaux. On peut utiliser des dendrimères en étoile, notamment des dendrimères en étoile de polyamidoamine, en tant qu'adjuvants de l'antigène d'Influenza et de matériaux similaires. Des dendrimères de mi-génération sont préférés et ils produisent des niveaux élevés de titres d'anticorps avec un dosage limité d'antigène.

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