Adjuvanted influenza vaccines including cytokine-inducing...

Details Adjuvanted influenza vaccines including cytokine-inducing... Adjuvanted influenza vaccines including cytokine-inducing...

A - Human Necessities

61

K

A61K 39/145 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2628424

While oil-in-water emulsions are excellent adjuvants for influenza vaccines, their efficacy can be improved by additionally including other immunostimulating agent(s) to improve cytokine responses, such as .gamma.- interferon response. Thus a vaccine comprises: (i) an influenza virus antigen; (ii) an oil-in-water emulsion adjuvant; and (iii) a cytokine-inducing agent.

Si les émulsions huile dans eau s'avèrent être d'excellents adjuvants pour des vaccins influenza, leur efficacité peut être accrue par ajout d'autres agents d'immunostimulation afin d'améliorer les réponses des cytokines, de type réponses d'interféron ?. A cet effet, l'invention propose un vaccin qui comprend : (i) un antigène du virus influenza ; (ii) un adjuvant de type émulsion huile dans eau ; et (iii) un agent d'induction de cytokines.

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