Adjuvants for vaccines against respiratory syncytial virus

Details Adjuvants for vaccines against respiratory syncytial virus Adjuvants for vaccines against respiratory syncytial virus

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/155 (2006.01)

Patent

CA 2163550

Vaccine formulations and therapeutic methods therefor containing respiratory syncytial viral proteins or immunological fragment and an adjuvant selected from the group consisting of QS-21, 3-deaclylated monophosphoryl lipid A, monophosphoryl lipid A and combination are described herein. Presence of the adjuvant(s) significantly increases the humoral and cell-mediated immunogenicity of the RSV proteins.

L'invention concerne des formulations de vaccins ainsi que leurs méthodes thérapeutiques, contenant des protéines du virus respiratoire syncytial ou un fragment immunologique ainsi qu'un adjuvant choisi dans le groupe comprenant QS-21, le lipide A de monophosphoryle désacylé en position 3, le lipide A de monophosphoryle ainsi qu'une combinaison. La présence du ou des adjuvant(s) augmente sensiblement l'immunogénicité humorale et induite par des cellules des protéines du virus respiratoire syncytial.

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