Adjuvation through cross-.beta. structure

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/12 (2006.01)

Patent

CA 2615020

The invention relates to novel methods and means for providing proteinaceous substances, such as peptides, polypeptides, glycoproteins, lipoproteins and complex compounds comprising the former in combination with other substances, such as nucleic acids, membrane structures, carbohydrate structures, with cross-.beta. structures, which enhance the immunogenicity of said proteinaceous substance. The resulting peptides, proteins, glycoproteins, etc. are preferably used in vaccines. The invention provides a method for producing an immunogenic composition comprising at least one peptide, polypeptide, protein, glycoprotein and/or lipoprotein, comprising providing said composition with at least one cross-.beta. structure. The invention also discloses the use of cross-.beta. structures in the preparation of a vaccine for the prophylaxis of an infectious disease. The invention further provides a method for improving immunogenicity of a composition comprising at least one peptide, polypeptide, protein, glycoprotein and/or lipoprotein, comprising contacting at least one of said peptide, polypeptide, protein, glycoprotein and/or lipoprotein with a cross-.beta. inducing agent, thereby providing said composition with additional cross-.beta. structures.

Procédés et systèmes permettant de fournir des substances protéinacées, du type peptides, polypeptides, glycoprotéines, lipoprotéines et complexes les renfermant en combinaison avec d'autres substances, du type acides nucléiques, structures à hydrates de carbone, structures à membrane, structures à hydrates de carbone, à structures bêta-croisées, qui améliorent l'immunogénicité de la substance protéinacée. Il en résulte des peptides, protéines, glycoprotéines, etc. que l'on utilise de préférence dans les vaccins. On décrit un procédé de production de composition immunogène qui renferme au moins un peptide, un polypeptide, une protéine une glycoprotéine et/ou une lipoprotéine, consistant à fournir ladite composition avec au moins une structure bêta-croisée. On décrit aussi l'utilisation de ces structures bêta-croisées dans la production de vaccin pour la prophylaxie de maladie infectieuse. L'invention concerne enfin un procédé permettant d'améliorer l'immunogénicité d'une composition qui renferme au moins un peptide, un polypetide, une protéine, une glycoprotéine et/ou une lipoprotéine, par contact entre au moins l'un de ces éléments (peptide, etc.) avec un agent d'induction bêta-croisée, ce qui confère à ladite composition des structures bêta-croisées additionnelles.

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