Administration of a thiol-based chemoprotectant compound

Details Administration of a thiol-based chemoprotectant compound Administration of a thiol-based chemoprotectant compound

A - Human Necessities

61

K

A61K 31/198 (2006.01) A61K 9/08 (2006.01) A61K 45/00 (2006.01) A61P 39/00 (2006.01)

Patent

CA 2406081

A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors. The thiol-based chemoprotectant agent is administered intra-arterially with rapid and first pass uptake in organs and tissues other than the liver.

L'invention concerne une méthode d'administration d'un agent chimioprotecteur à base de thiol, comprenant du NAC (N-acétylcystéine) et du STS (thiosulfate de sodium), qui modifie sensiblement la biorépartition et protège contre les blessures consécutives à des procédures diagnostiques ou thérapeutiques intra-artérielles. L'invention porte également sur une méthode de traitement ou d'atténuation des effets secondaires du traitement anticancéreux cytotoxique contre les tumeurs situées dans la tête, le cou ou le cerveau. Ledit agent chimioprotecteur à base de thiol est administré par voie intra-artérielle, avec une absorption rapide et en une seule fois dans les organes et les tissus autres que le foie.

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