A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 9/00 (2006.01) A61K 31/27 (2006.01) A61K 31/435 (2006.01) A61K 31/473 (2006.01) A61K 31/48 (2006.01) A61K 31/55 (2006.01) A61K 31/724 (2006.01) A61K 45/06 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2482161
Methods and compositions are disclosed that provide acetylcholinesterase inhibitors for the prevention and treatment of diseases and disorders of the central nervous system, including dementia such as Alzheimer's disease, to the central nervous system via intranasal delivery. The methods and compositions of the present invention provide therapeutic concentrations of the acetylcholinesterase inhibitor in the cerebrospinal fluid of a mammal without the attendant disadvantages, risks and side effects of oral or injection delivery.
L'invention concerne des méthodes et des compositions permettant de distribuer au système nerveux central, via une administration intranasale, des inhibiteurs de l'acétylcholinestérase dans la prévention et le traitement de maladies et de troubles du système nerveux central, notamment la démence, telle que la maladie d'Alzheimer. Ces méthodes et ces compositions présentent des concentrations thérapeutiques de l'inhibiteur de l'acétylcholinestérase dans le fluide céphalorachidien spinal d'un mammalien, sans comporter les désavantages, les risques et les effets indésirables associés d'une administration buccale ou par injection.
Borden Ladner Gervais Llp
Nastech Pharmaceutical Company Inc.
LandOfFree
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