A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/545 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01)
Patent
CA 2280718
The present invention provides for a method of injecting an antibiotic in the ear of an animal, such as cattle, swine, sheep and goats. These injectable antibiotics include the following: injectable suspensions of sparingly water-soluble antimicrobial agents, such as procaine penicillin, benzathine penicillin, ceftiofur crystalline free acid of formula (I), ceftiofur hydrochloride, ampicillin trihydrate and amoxicillin trihydrate; sustained-release non-aqueous solutions of sparingly water-soluble antimicrobial agents, such as oxytetracycline, erythromycin, tylosin, tilmicosin and florfenicol; and injectable solutions of zwitterionic antimicrobial agents, such as enrofloxycin, danofloxacin, premafloxacin, ceftiofur sodium, and lincomycin hydrochloride. Specifically, the present invention provides for a method of injecting a relatively large volume (1 to 15 mL) of a sterile oil suspension of an antibiotic, such as ceftiofur crystalline free acid, in the posterior of the ear of cattle and swine. The compound of formula (I) is also named 7-[2-(2-amino-1,3-thiazol-4-yl) -2-methoxyimino)acetamino]-3-[(fur-2-ylcarbonyl)thiomethyl] -3-cephem-4- carboxylic acid.
Procédé pour injecter un antibiotique dans l'oreille d'un animal tel qu'un bovin, un porc, un mouton ou une chèvre. Ces antibiotiques injectables contiennent les composants suivants: des suspensions injectables d'agents antimicrobiens modérément solubles à l'eau tels que la procaïne-pénicilline, la benzathine-pénicilline, l'acide libre cristallin de ceftiofur défini dans la formule (I), le chlorhydrate de ceftiofur, le trihydrate d'ampicilline et le trihydrate d'amoxicilline; des solutions non aqueuses et à libération prolongée d'agents antimicrobiens modérément solubles à l'eau tels que l'oxytétracycline, l'érythromycine, la tylosine, la tilmicosine et le florfénicol; et des solutions injectables d'agents antimicrobiens zwitterioniques tels que l'enrofloxacine, la danofloxacine, la prémafloxacine, le ceftiofur sodium et le chlorhydrate de lincomycine. L'invention concerne en particulier un procédé pour injecter un volume relativement important (1 à 15 mL) d'une suspension huileuse stérile d'un antibiotique, tel que l'acide libre cristallin de ceftiofur, dans la partie postérieure de l'oreille de bovins et de porcs. (I) Le composé représenté dans la formule (I) est également appelé acide 7-[2-(2-amino-1,3-thiazol-4-yl) -2-méthoxyimino)acétamidol]-3-[(fur-2-ylcarbonyl)thiométhyl] -3-céphem-4-carboxylique.
Macrae & Co.
Pharmacia & Upjohn Company
LandOfFree
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